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With or without a working knowledge of cannabis, most dispensary consumers have a speaking acquaintance with the compounds THC and CBD. But scientists are flirting with lesser known kinfolk in the cannabinoid family, compounds which are for the most part non-psychoactive but have intriguing potential health benefits. One such cannabinoid is Cannabinol, known in the industry as CBN.
CBN is a non-psychoactive cannabinoid that is a breakdown product of the cannabis superstar tetrahydrocannabinol (THC), the plant’s most abundant constituent best known for the plant’s psychoactive “high.” As the THC in cannabis buds ages, it transforms into cannabinol through a process known as oxidation.
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GW Pharmaceuticals plc (Nasdaq: GWPH, “GW,” “the Company” or “the Group”), a biopharmaceutical company focused on discovering, developing and commercializing novel therapeutics from its proprietary cannabinoid product platform, along with its U.S. subsidiary Greenwich Biosciences, announced today that The New England Journal of Medicine has published results from a Phase 3 study of Epidiolex® (cannabidiol) in children with Dravet syndrome.1 Epidiolex, GW’s lead product candidate and the potential first in a new category of anti-epileptic drugs, is a liquid formulation of purified, plant-derived cannabidiol (CBD), a non-psychoactive cannabinoid, which is being studied for the treatment of a number of rare, severe pediatric-onset epilepsy disorders. In the study, Epidiolex significantly reduced monthly convulsive seizure frequency compared to placebo in highly treatment-resistant children when added to existing treatment. Treatment with Epidiolex was generally well tolerated, with a safety profile consistent with prior open label experience.
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